Caldesene Medicated Protecting Powder with Zinc Oxide & Cornstarch Talc Free, 5 Ounce. This gentle powder is recognized as safe and effective by moms and doctors in treating diaper rash, prickly heat, and chafing. Caldesene Cornstarch Powder with Zinc Oxide. Contains cornstarch and zinc oxide which form a protective barrier to repel moisture and help keep skin dry. When used regularly, Caldesene soothes and softens your baby's delicate skin and seals out wetness to help protect against chafed skin.